A Self-Gelling Powder Based on Polyacrylic Acid/ Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity

Powder-based hemostatic materials has offered unprecedented opportunities in effective sealing and repair of irregularly shaped wound and high-pressure, noncompressible arterial bleeding wounds caused by surgeries, traffic accidents and wars. However, inadequate adhesion to bleeding wounds or poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling hemostasis powder based on polyacrylic acid/ polyethyleneimine/ polyethylene glycol（named as PPG）for rapid hemostasis and effective antibacterial ability. PPG powder deposited on bleeding wounds can absorb interfacial water and rapidly swell into a physically cross-linked hydrogel in situ within 2 seconds to form a pressure-resistant physical barrier. Furthermore, the in vivo and in vitro result indicate the PPG powder as an effective sealant possesses ease of use, excellent hemocompatibility, strong antibacterial abilities, and superior blood clotting abilities. The effective hemostatic sealing capability of the PPG powder is demonstrated in a variety of injury models in rats and rabbits. All of these factors show that the PPG powder with superior wound treatment abilities is a profound biomaterial for surgical applications.