医学
补体系统
肾小球疾病
替代补体途径
补语(音乐)
免疫学
发病机制
伊库利珠单抗
肾脏疾病
经典补体途径
肾
肾小球肾炎
抗体
内科学
生物
表型
互补
基因
生物化学
作者
Benjamin Wooden,Blanca Tarragon,Mariela Navarro-Torres,Andrew S. Bomback
摘要
ABSTRACT A refined understanding of the role of complement in the pathogenesis of glomerular and other kidney diseases has, over the past two decades, been matched by the development of novel, complement-targeting therapies. As we increasingly recognize the important role that complement activation across all three pathways—classical, lectin and alternative—plays in glomerular lesions both rare (e.g. C3 glomerulopathy) and common (e.g. immunoglobulin A nephropathy), we can identify avenues for precise, targeted approaches to modifying the natural history of these kidney diseases. In this review, we survey the evidence on using complement inhibition from the earliest, small-scale studies focusing on C5-targeting agents to more recent, large, multicenter, randomized trials utilizing complement blockade higher up in the complement pathway at the level of C3. We conclude by examining where the field of complement targeting therapy may be headed in light of these studies.
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