Probiotics for the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications

医学 益生菌 小儿胃肠病 重症监护医学 腹泻 随机对照试验 小肠结肠炎 内科学 肝病学 肠道菌群 坏死性小肠结肠炎 免疫学 遗传学 生物 细菌
作者
Hania Szajewska,Roberto Berni Canani,Magnus Domellöf,Alfredo Guarino,Iva Hojsak,Flavia Indrio,Andrea Lo Vecchio,Walter A. Mihatsch,Alexis Mosca,Rok Orel,Silvia Salvatore,Raanan Shamir,Chris H.P. van den Akker,Johannes B. van Goudoever,Yvan Vandenplas,Zvi Weizman
出处
期刊:Journal of Pediatric Gastroenterology and Nutrition [Ovid Technologies (Wolters Kluwer)]
卷期号:76 (2): 232-247 被引量:75
标识
DOI:10.1097/mpg.0000000000003633
摘要

Background: Probiotics, defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are widely used despite uncertainty regarding their efficacy and discordant recommendations about their use. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Gut Microbiota and Modifications provides updated recommendations for the use of probiotics for the management of selected pediatric gastrointestinal disorders. Methods: All systematic reviews and/or meta-analyses, as well as subsequently published randomized controlled trials (RCTs) (until December 2021), that compared the use of probiotics in all delivery vehicles and formulations, at any dose, with no probiotic (ie, placebo or no treatment), were eligible for inclusion. The recommendations were formulated only if at least 2 RCTs on a similar well-defined probiotic strain were available. The modified Delphi process was used to establish consensus on the recommendations. Results: Recommendations for the use of specific probiotic strains were made for the management of acute gastroenteritis, prevention of antibiotic-associated diarrhea, nosocomial diarrhea and necrotizing enterocolitis, management of Helicobacter pylori infection, and management of functional abdominal pain disorders and infant colic. Conclusions: Despite evidence to support the use of specific probiotics in some clinical situations, further studies confirming the effect(s) and defining the type, dose, and timing of probiotics are still often required. The use of probiotics with no documented health benefits should be discouraged.
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