Occurrence of some legacy and emerging contaminants in feed and food and their ranking priorities for human exposure

The "feed-to-food" pathway is one of the most important routes for human exposure to manmade contaminants. The contaminants could threaten human health through the "feed-to-food" route and have recently become of great public concern. This review selects the representative legacy and emerging contaminants (ECs), such as polybrominated diphenyl ethers (PBDEs), novel brominated flame retardants (NBFRs), organophosphate esters (OPEs), short-chain chlorinated paraffins (SCCPs), and per- and polyfluoroalkyl substances (PFASs), regarding their occurrence in feed and food, as well as their metabolites and transport in farming and livestock ecosystems. Factors that might influence their presence and behavior are discussed. This review raises an approach to rank the priority of ECs using the EC concentrations in feed and food and using the hazard quotient (HQ) method for human health. Although SCCPs have the highest levels in feed and food, their potential risks appear to be the lowest. PFASs have the highest HQs on account of human exposure risk. Future research should pay more attention to the combined effects of multiple ECs.