Clinical evaluation of different sepsis filters

Sepsis is a life-threatening organ dysfunction in response to a host's infection. In addition to treatments with proven efficacy in sepsis, there are also treatment methods under investigation. The use of cytokine filters is recognized as a promising adjunctive therapy in the treatment of sepsis. The aim of this study is to evaluate the results of sepsis cytokine filters applied in sepsis patients. In this retrospective single center study, 17 patients who were followed up in the Internal Diseases Intensive Care Clinic of Kayseri City Hospital due to sepsis and were applied sepsis cytokine filter were included in the study. Three sepsis filters were applied to the patients according to their clinical status. CPFA sepsis filter was applied in 5 patients(Group 1), Oxiris in 7 patients(Group 2), and Jafron HA330 in 5 patients(Group 3). The mean age of the patients was 67.1 ± 17.9 years. Seven of the patients were femal (41%) and 10 were male(59%). The hospitalization period of the patients was 30.1 ± 32.3 days and the day of hospitalization in the intensive care unit was 11.1 ± 8.8 days. The mean APACHE value of the patients was 32.8 ± 7.1 and the hospitalization glaskow coma score was 10.3 ± 3.3. There was a significant difference between the glaskow coma score at the intensive care unit admission and the glaskow coma score at the time of discharge from the intensive care unit (p = 0.010). CRP decrease rates and procalcitonin decrease rates before and after sepsis filter were significant, but WBC decrease rate was not significant (p < 0.001, p = 0.001, and p = 0.570, respectively). Procalcitonin decrease percentages of the patients were 0.87 ± 0.15, and CRP decrease percentages were 0.64 ± 0.31. The percentages of decrease in Procalcitonin were found to be significant in the CPFA sepsis filter applied group compared to the groups in which Oxiris and Jafron HA330 were applied (p = 0.020), there was no difference between the three groups in terms of CRP decrease percentages (p = 0.755). There was no difference in mortality between the groups. Sepsis cytokine filters have been shown in many studies to contribute positively to reducing procalcitonin and CRP values. It has been reported that cytokine filters used in selected sepsis patients have positive effects on mortality. The significant decrease in the percentage of procalcitonin in CPFA may be due to the smaller pore size. Studies to be conducted in larger patient groups will be appropriate in terms of evaluating the effect on mortality.