Investigating cyclization selectivity by ligand tuning based on MHAT/RPC mechanism

In this study, we investigated the metal-catalyzed hydrogen atom transfer (MHAT)/radical polar crossover (RPC) reaction, focusing on the influence of ligands on the cyclization selectivity by employing substrates containing two nucleophiles along with an alkene. We provide new insights into the importance of ligand optimization in the MHAT/RPC mechanism, particularly in hydroarylation reactions.