粒体自噬
品脱1
帕金
自噬
白藜芦醇
神经保护
张力素
PTEN公司
机制(生物学)
线粒体生物发生
生物
PI3K/AKT/mTOR通路
药理学
神经科学
计算生物学
线粒体
信号转导
细胞生物学
医学
帕金森病
疾病
生物化学
细胞凋亡
哲学
认识论
病理
作者
Xinyu Lin,Wenkai Liu,Xizhuo Hu,Zhiqiang Liu,Li Wang,Jinlian Wang
标识
DOI:10.1016/j.phrs.2024.107324
摘要
This review rigorously assesses the burgeoning research into the role of polyphenols in modulating mitophagy, an essential cellular mechanism for the targeted removal of impaired mitochondria. These natural compounds, known for their low toxicity, are underscored for their potential in therapeutic strategies against a diverse array of diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply into the molecular mechanisms whereby polyphenols promote mitophagy, particularly by influencing crucial signaling pathways and transcriptional regulators, including the phosphatase and tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin and forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include the neuroprotective properties of resveratrol and curcumin, which affect both autophagic pathways and mitochondrial dynamics, and the pioneering integration of polyphenols with other natural substances to amplify therapeutic effectiveness. Furthermore, the review confronts the issue of polyphenol bioavailability and emphasizes the imperative for clinical trials to corroborate their therapeutic viability. By delivering an exhaustive synthesis of contemporary insights and recent advancements in polyphenol and mitophagy research, this review endeavors to catalyze additional research and foster the creation of innovative therapeutic modalities that exploit the distinctive attributes of polyphenols to manage and prevent disease.
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