化学
部分
吡唑
磺胺
终端(电信)
消炎药
立体化学
组合化学
药理学
医学
电信
计算机科学
作者
Mohammed S. Abdel‐Maksoud,S. A. Nasser,Rasha M. Hassan,Walaa Hamada Abd‐Allah
标识
DOI:10.1016/j.bioorg.2024.107825
摘要
In the present work, a new series of ethyl pyrazole-containing compounds with side sulphonamide moiety was designed and synthesized. The new derivatives were divided into four groups based on the linker between the sulphonamide and pyridine ring attached to position 4 of the pyrazole ring and the substitution on the phenyl ring at position 3 of the same ring. The linker could be ethyl or propyl linkers. The phenyl ring is substituted with a methoxy group or hydroxyl group at position 3. The aim compounds were tested for their JNK1, JNK2, JNK3, and BRAF(V600E) activities. Compounds 23b, 23c, and 23d showed the highest activity with nanomolar IC
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