Two new quinolinone glycoalkaloids from Chrysanthemum indicum L. and their antimicrobial activity

AbstractPhytochemical investigation of Chrysanthemum indicum L. yielded two new quinolinone glycoalkaloids named as Chrysanthemumsides A-B (1-2). The structures of the new compounds were elucidated by analysis of their 1D- and 2D-NMR, HRESIMS and ECD calculations. Compounds 1-4 were evaluated for antimicrobial activity against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, and the data showed that compound 2 had significant antimicrobial effects (MIC 3.9 to 7.8 μg/mL).Keywords: Chrysanthemum indicum L.compositaequinolinone glycoalkaloidsantimicrobial activity AcknowledgementsThe work was financially supported by the Henan Programs for Science and Technology Development (No. 222102110443), the Science and Technology Major Projects in Henan Science and Technology Agency (No. 20111310900), the Science and Technology Innovation Team in Xinyang Agriculture and Forestry University (No. KJCXTD-202005; XNKJTD-009).Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.