非布索坦
高尿酸血症
痛风
黄嘌呤氧化酶
虚拟筛选
药理学
化学
关节炎
IC50型
对接（动物）
炎症体
尿酸
黄嘌呤氧化酶抑制剂
别嘌呤醇
体外
医学
生物化学
酶
内科学
受体
药物发现
护理部
作者
Min‐Yi Lv,Shaoyan Jiang,Shaojie Deng,Zean Zhao,Zichao Yang,Lu Liu,Tao Ke
标识
DOI：10.1021/acs.jnatprod.3c00099
摘要
In the present study, a natural product database of compounds associated with herbs traditionally verified to treat gout/hyperuricemia/arthritis was constructed. 3D-shape and docking-based virtual screening was conducted. To identify potential xanthine oxidase (XOD) inhibitors in the database, eight compounds with commercial availability were identified as high 3D-shape similarity with febuxostat (
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