神经退行性变
蛋白酶体
蛋白质聚集
发病机制
疾病
生物
神经科学
泛素
细胞外
溶酶体
细胞生物学
细胞内
医学
生物化学
免疫学
酶
基因
病理
作者
Mari Takalo,Antero Salminen,Hilkka Soininen,Mikko Hiltunen,Annakaisa Haapasalo
出处
期刊:PubMed
日期:2013-01-01
被引量:179
摘要
Neurodegenerative diseases are characterized by selective neuronal vulnerability and neurodegeneration in specific brain regions. The pathogenesis of these disorders centrally involves abnormal accumulation and aggregation of specific proteins, which are deposited in intracellular inclusions or extracellular aggregates that are characteristic for each disease. Increasing evidence suggests that genetic mutations or environmental factors can instigate protein misfolding and aggregation in these diseases. Consequently, neurodegenerative diseases are often considered as conformational diseases. This idea is further supported by studies implicating that impairment of the protein quality control (PQC) and clearance systems, such as the ubiquitin-proteasome system and autophagosome-lysosome pathway, may lead to the abnormal accumulation of disease-specific proteins. This suggests that similar pathological mechanisms may underlie the pathogenesis of the different neurodegenerative disorders. Interestingly, several proteins that are known to associate with neurodegenerative diseases have been identified as important regulators of PQC and clearance systems. In this review, we summarize the central features of abnormal protein accumulation in different common neurodegenerative diseases and discuss some aspects of specific disease-associated proteins regulating the PQC and clearance mechanisms, such as ubiquilin-1.
科研通智能强力驱动
Strongly Powered by AbleSci AI