溃疡性结肠炎
胃肠病学
医学
发病机制
内科学
临床意义
白细胞介素23
白细胞介素10
白细胞介素17
血清浓度
结肠炎
白细胞介素8
免疫学
炎症
细胞因子
疾病
作者
Zheng Zi-dan,Xiaoqiang Wan,Liang-ying Liu
出处
期刊:PubMed
日期:2011-02-01
卷期号:27 (2): 203-6
被引量:13
摘要
To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance.40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected. The serum contents of IL-23 and IL-17 were determined bII ELISA.Serum contents of IL-23 AND IL-17 in UC group were higher than those in control group significantly (t=18.76, 21.48, P<0.01). Serum contents of IL-23 and IL-17 increase with the clinical symptoms. Serum contents of IL-23 AND IL-17 in severe patients were higher than those of mild and moderate patients significantly, and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly. Serum contents of IL-23 were positively correlated to IL-17 significantly (r=0.548, P<0.01).IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis. IL-23 may play a critical role in the development of UC through inducing production of IL-17.
科研通智能强力驱动
Strongly Powered by AbleSci AI