粘菌素
肺炎克雷伯菌
生物
插入顺序
微生物学
拉伤
抗生素
抗药性
MCR-1型
鲍曼不动杆菌
多重耐药
全基因组测序
质粒
美罗培南
碳青霉烯
抗生素耐药性
基因
多位点序列分型
遗传学
脉冲场凝胶电泳
病毒学
基因组
大肠杆菌
转座因子
解剖
作者
Björn Berglund,Ngoc Thi Bich Hoang,Maria Tärnberg,Ngai Kien Le,Olov Svartström,Dung Thi Khanh Khu,Måns Nilsson,Hai Thanh Le,Jenny Welander,Linus Olson,Mattias Larsson,Lennart Nilsson,Håkan Hanberger
标识
DOI:10.1016/j.ijantimicag.2017.11.012
摘要
Resistance among Klebsiella pneumoniae to the last-resort antibiotics carbapenems and colistin is increasing worldwide. In this study, whole-genome sequencing was used to determine the colistin resistance mechanisms in clinical isolates of carbapenem- and colistin-resistant K. pneumoniae from Vietnam. Alterations in the regulatory gene mgrB, via mutations and insertion sequence transpositions, were found in 30 of 31 isolates, emphasising the importance of this resistance mechanism in colistin-resistant K. pneumoniae.
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