多细胞生物
有机体
癌症
计算生物学
生物
独创性
癌细胞
计算机科学
细胞
遗传学
新古典经济学
经济
作者
Anupam K. Chakravarty,Daniel J. McGrail,Thomas M. Lozanoski,Brandon S. Dunn,David Shih,Kara M. Cirillo,Sueda H Cetinkaya,W. Jim Zheng,Gordon B. Mills,S. Stephen Yi,Daniel F. Jarosz,Nidhi Sahni
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2022-07-19
卷期号:12 (9): 2031-2043
被引量:4
标识
DOI:10.1158/2159-8290.cd-21-1605
摘要
Multicellularity was a watershed development in evolution. However, it also meant that individual cells could escape regulatory mechanisms that restrict proliferation at a severe cost to the organism: cancer. From the standpoint of cellular organization, evolutionary complexity scales to organize different molecules within the intracellular milieu. The recent realization that many biomolecules can "phase-separate" into membraneless organelles, reorganizing cellular biochemistry in space and time, has led to an explosion of research activity in this area. In this review, we explore mechanistic connections between phase separation and cancer-associated processes and emerging examples of how these become deranged in malignancy.One of the fundamental functions of phase separation is to rapidly and dynamically respond to environmental perturbations. Importantly, these changes often lead to alterations in cancer-relevant pathways and processes. This review covers recent advances in the field, including emerging principles and mechanisms of phase separation in cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI