上睑下垂
免疫疗法
癌症研究
葡萄糖氧化酶
放射治疗
免疫检查点
免疫系统
化疗
癌症免疫疗法
免疫原性细胞死亡
转移
癌症
材料科学
医学
程序性细胞死亡
细胞凋亡
纳米技术
生物
免疫学
内科学
生物化学
生物传感器
作者
Sijia Zhang,Ying Zhang,Yuanji Feng,Jiayan Wu,Yingying Hu,Lin Lin,Caina Xu,Jie Chen,Zhaohui Tang,Huayu Tian,Xuesi Chen
标识
DOI:10.1002/adma.202206851
摘要
Currently, immune checkpoint therapy combined with chemotherapy and radiotherapy is a useful strategy for improving immunotherapy's therapeutic efficacy. However, chemotherapy and radiotherapy cause serious side effects, so finding safe and effective methods to combine with immunotherapy is critical. In this work, regulating tumor glycometabolism is found to induce tumor cell pyroptosis and regulate the degree of expression of programmed death-ligand 1 (PD-L1). Therefore, how to treat tumors by regulating tumor glycometabolism in combination with anti-PD-L1 therapy is investigated here. First, the biomineralization-like method is used to construct nanoparticles with two-enzymatic activity by hybridizing nanozymes and glucose oxidase (GOx). It has the ability to self-amplify regulation of the glycometabolism of tumor cells. It can also induce tumor cell pyroptosis and increase the expression of PD-L1 in tumor cells. To treat tumors, nanoparticles are further combined with anti-PD-L1, which substantially inhibits tumor development and significantly increases the survival time of mice. Combination therapy also has a significant immunological memory effect, successfully preventing tumor recurrence and metastasis. This is thought to be the first study that combines tumor glycometabolism with immunocheckpoint blocking in cancer therapy. This innovative, safe, low-toxic, and highly effective anti-tumor strategy can have good prospects in clinical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI