Open-Label, Phase II Study of Talimogene Laherparepvec Plus Pembrolizumab for the Treatment of Advanced Melanoma That Progressed on Prior Anti–PD-1 Therapy: MASTERKEY-115,

Treatment options for immunotherapy-refractory melanoma are an unmet need. The MASTERKEY-115 phase II, open-label, multicenter trial evaluated talimogene laherparepvec (T-VEC) plus pembrolizumab in advanced melanoma that progressed on prior programmed cell death protein-1 (PD-1) inhibitors.