微生物群
生物
癌症
背景(考古学)
共生
计算生物学
生物信息学
免疫学
遗传学
细菌
古生物学
作者
Aurelia Saftien,Marius Mathies,Eran Elinav
出处
期刊:Gut
[BMJ]
日期:2023-05-05
卷期号:72 (7): 1410-1425
被引量:13
标识
DOI:10.1136/gutjnl-2022-327952
摘要
The microbiome may impact cancer development, progression and treatment responsiveness, but its fungal components remain insufficiently studied in this context. In this review, we highlight accumulating evidence suggesting a possible involvement of commensal and pathogenic fungi in modulation of cancer-related processes. We discuss the mechanisms by which fungi can influence tumour biology, locally by activity exerted within the tumour microenvironment, or remotely through secretion of bioactive metabolites, modulation of host immunity and communications with neighbouring bacterial commensals. We examine prospects of utilising fungi-related molecular signatures in cancer diagnosis, patient stratification and assessment of treatment responsiveness, while highlighting challenges and limitations faced in performing such research. In all, we demonstrate that fungi likely constitute important members of mucosal and tumour-residing microbiomes. Exploration of fungal inter-kingdom interactions with the bacterial microbiome and the host and decoding of their causal impacts on tumour biology may enable their harnessing into cancer diagnosis and treatment.
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