病理
滤泡树突状细胞
免疫分型
组织细胞
恶性肿瘤
间充质干细胞
医学
间质细胞
肉瘤
生物
T细胞
免疫学
抗原提呈细胞
免疫系统
流式细胞术
作者
Ramandeep Kaur,Jay Mehta,Anita Borges
出处
期刊:Advances in Anatomic Pathology
[Ovid Technologies (Wolters Kluwer)]
日期:2020-09-25
卷期号:28 (1): 21-29
被引量:18
标识
DOI:10.1097/pap.0000000000000281
摘要
Follicular dendritic cell sarcoma (FDCS) is an intermediate-grade malignancy of follicular dendritic cells, which are derived from mesenchymal stem cells. Nodal FDCS is well-recognized. However, when it occurs at an extranodal site, it may not be recognized and is often misdiagnosed. These tumors exhibit a variable spindle to epithelioid cell morphology with a lymphocytic infiltrate and a distinct immunophenotype. The World Health Organization has classified this entity under tumors of hematopoietic and lymphoid tissue, that is, histiocytic and dendritic cell neoplasms. However, its occurrence at extranodal sites and its behavior and management more closely resemble that of a soft tissue tumor. Increased awareness about the existence of FDCS at extranodal sites may aid in the reduction of diagnostic errors. We wish to draw attention to this entity by reporting our experience of 54 cases of extranodal FDCS encountered over a period of 14 years and present a review of the literature of this underrecognized entity. We also describe the ontogeny and molecular pathogenesis of this uncommon lesion.
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