DPPH
吲哚试验
立体化学
化学
真菌
绝对构型
抗菌剂
抗氧化剂
有机化学
生物
植物
作者
Weihao Chen,Kunlong Li,Xiuping Lin,Shengrong Liao,Bin Yang,Xuefeng Zhou,Junjian Wang,Yonghong Liu,Junfeng Wang
标识
DOI:10.1080/14786419.2020.1749614
摘要
Twelve indole alkaloids, including α-cyclopiazonic acid (CPA) (1), nine 2-oxo indole CPA derivatives (2-10), and two open-ring indole CPA derivatives (11 and 12), were isolated from the fermentation broth of a deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures and absolute configurations were elucidated mainly by using extensive NMR spectroscopic, mass spectrometric and single crystal X-ray diffraction analysis. To the best of our knowledge, the crystallographic data of 3 and 7 were firstly reported, and the absolute configuration of 3 was confirmed for the first time by the single crystal X-ray diffraction analysis. Most isolated compounds were tested for their antimicrobial, antitumor and radical scavenging activities. In addition, compounds 1, 2 and 11 showed moderate antioxidative activity against DPPH with IC50 values of 190.1, 31.9, 228.4 μg/mL, respectively.
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