体内分布
体内
纳米医学
介孔二氧化硅
纳米技术
材料科学
纳米颗粒
药物输送
共轭体系
体外
化学
癌症研究
生物物理学
生物医学工程
介孔材料
医学
生物化学
生物技术
复合材料
催化作用
生物
聚合物
作者
Mauro Ferrari,Feng Chen,Shijie Luan,Hector F. Valdovinos,Sixiang Shi,Stephen A. Graves,Fanrong Ai,Todd E. Barnhart,Charles P. Theuer,Weibo Cai
标识
DOI:10.1002/advs.201600122
摘要
A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self‐destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as‐synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium‐89 ( 89 Zr, t 1/2 = 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging. Rapid and persistent CD105 specific tumor vasculature targeting is successfully demonstrated in murine model of metastatic breast cancer by using TRC105 (an anti‐CD105 antibody)‐conjugated bMSNs. This study serves to illustrate a simple, versatile, and readily tunable approach to potentially overcome the current challenges facing nanomedicine and further the goals of personalized nanotheranostics.
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