脂联素
内科学
哺乳期
内分泌学
乳腺
生物
受体
催乳素
激素
脂联素受体1
脂肪组织
脂肪细胞
信使核糖核酸
基因表达
胰岛素
胰岛素抵抗
基因
医学
生物化学
怀孕
遗传学
癌症
乳腺癌
作者
Yoshihisa Ohtani,Tomo Yonezawa,Sang‐Houn Song,Teruyuki Takahashi,Astrid Ardiyanti,Katsuyoshi Sato,Akihiko Hagino,Sanggun Roh,Kazuo Katoh
标识
DOI:10.1111/j.1740-0929.2010.00805.x
摘要
ABSTRACT Although the functions of adiponectin, a differentiated adipocyte‐derived hormone, in regulating glucose and fatty acid metabolism are regulated by two subtypes of adiponectin receptors (AdipoRs; AdipoR1 and AdipoR2), those in ruminants remain unclear. Therefore we examined the messenger RNA (mRNA) expression levels of adiponectin and its receptors in various bovine tissues and mammary glands among different lactation stages, and the effects of lactogenic hormones (insulin, dexamethasone and prolactin) and growth hormone (GH) on mRNA expression of the AdipoRs in cultured bovine mammary epithelial cells (BMEC). AdipoRs mRNAs were widely expressed in various bovine tissues, but adiponectin mRNA expression was significantly higher in adipose tissue than in other tissues. In the mammary gland, although adiponectin mRNA expression was significantly decreased at lactation, AdipoR1 mRNA expression was significantly higher at peak lactation than at the dry‐off stage. In BMEC, lactogenic hormones and GH upregulated AdipoR2 mRNA expression but did not change that of AdipoR1. In conclusion, adiponectin and its receptor mRNA were expressed in various bovine tissues and the adiponectin mRNA level was decreased during lactation. These results suggest that adiponectin and its receptors ware changed in mammary glands by lactation and that AdipoRs mRNA expression was regulated by different pathways in BMEC.
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