毛发生长
米诺地尔
毛囊
硫代硫酸钠
代谢物
化学
脱发
头发周期
氧化应激
药理学
内分泌学
生物化学
内科学
生物
皮肤病科
生理学
医学
无机化学
作者
Motoko Maekawa,Tetsuo Ohnishi,Shabeesh Balan,Yasuko Hisano,Yayoi Nozaki,Hisako Ohba,Manabu Toyoshima,Chie Shimamoto,Chinatsu Tabata,Yuina Wada,Takeo Yoshikawa
标识
DOI:10.1080/09168451.2018.1518705
摘要
ABSTRACT The present study describes the hair growth-promoting effects of sodium thiosulfate (STS), a widely used compound, in mice. STS accelerated hair growth in the “telogen model”, suggesting that it stimulates telogen hair follicles to reenter the anagen phase of hair growth. In the same model, STS potentiated hair growth in an additive manner with minoxidil (MXD), a drug used for the treatment of androgenic alopecia. Furthermore, in the “anagen model”, STS promoted hair growth, probably by promoting hair follicle proliferation. Since STS elevated the skin surface temperature, its hair growth-promoting activity may be partly due to vasorelaxation, similar to MXD. In addition, STS is known to generate a gaseous mediator, H2S, which has vasorelaxation and anti-inflammatory/anti-oxidative stress activities. Therefore, STS and/or provisionally its metabolite, H2S, may aid the hair growth process. Collectively, these results suggest that salts of thiosulfate may represent a novel and beneficial remedy for hair loss.
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