Pre-attentive Visual Processing in Alzheimer’s Disease: An Event-related Potential Study

P3b页 第3A页 怪胎范式 事件相关电位 听力学 心理学 神经心理学 刺激(心理学) 视觉处理 认知 认知心理学 发展心理学 神经科学 脑电图 医学 感知
作者
Eunchan Na,Kang-Hee Lee,Eun‐jin Kim,Jong Bin Bae,Seung Wan Suh,Seonjeong Byun,Ji Won Han,Ki Woong Kim
出处
期刊:Current Alzheimer Research [Bentham Science Publishers]
卷期号:17 (13): 1195-1207 被引量:4
标识
DOI:10.2174/1567205018666210216084534
摘要

Introduction: While identifying Alzheimer’s Disease (AD) in its early stages is crucial, traditional neuropsychological tests tend to lack sensitivity and specificity for its diagnosis. Neuropsychological studies have reported visual processing deficits of AD, and event-related potentials (ERPs) are suitable to investigate pre-attentive processing with superior temporal resolution. Objective: This study aimed to investigate visual attentional characteristics of adults with AD, from pre-attentive to attentive processing, using a visual oddball task and ERPs. Methods: Cognitively normal elderly controls (CN) and patients with probable AD (AD) were recruited. Participants performed a three-stimulus visual oddball task and were asked to press a designated button in response to the target stimuli. The amplitudes of 4 ERPs were analyzed. Mismatchnegativity (vMMN) was analyzed around the parieto-occipital and temporo-occipital regions. P3a was analyzed around the fronto-central regions, whereas P3b was analyzed around the centro-parietal regions. Results: Late vMMN amplitudes of the AD group were significantly smaller than those of the CN group, while early vMMN amplitudes were comparable. Compared to the CN group, P3a amplitudes of the AD group were significantly smaller for the infrequent deviant stimuli, but the amplitudes for the standard stimuli were comparable. Lastly, the AD group had significantly smaller P3b amplitudes for the target stimuli compared to the CN group. Conclusion: Our findings imply that AD patients exhibit pre-attentive visual processing deficits, known to affect later higher-order brain functions. In a clinical setting, the visual oddball paradigm could be used to provide helpful diagnostic information since pre-attentive ERPs can be induced by passive exposure to infrequent stimuli.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
sysi完成签到 ,获得积分10
9秒前
绿波电龙完成签到,获得积分10
10秒前
13秒前
ZZzz完成签到 ,获得积分10
14秒前
wujiwuhui发布了新的文献求助10
18秒前
20秒前
梦梦的小可爱完成签到 ,获得积分10
20秒前
xinjie发布了新的文献求助10
23秒前
25秒前
蛋花肉圆汤完成签到,获得积分10
25秒前
羞涩的文轩完成签到 ,获得积分10
26秒前
31秒前
32秒前
北城完成签到 ,获得积分10
34秒前
量子星尘发布了新的文献求助10
34秒前
37秒前
爱听歌电灯胆完成签到 ,获得积分10
37秒前
不爱吃西葫芦完成签到 ,获得积分10
38秒前
申燕婷完成签到 ,获得积分10
39秒前
橙子完成签到 ,获得积分10
41秒前
ruochenzu发布了新的文献求助10
41秒前
fusheng完成签到 ,获得积分10
50秒前
浮生完成签到 ,获得积分10
55秒前
xinjie完成签到,获得积分10
57秒前
Will完成签到,获得积分10
1分钟前
cuddly完成签到 ,获得积分10
1分钟前
掉头发的小白完成签到,获得积分10
1分钟前
不想看文献完成签到 ,获得积分10
1分钟前
1分钟前
当女遇到乔完成签到 ,获得积分10
1分钟前
独行者完成签到,获得积分10
1分钟前
眼睛大的电脑完成签到,获得积分10
1分钟前
1分钟前
敏敏发布了新的文献求助10
1分钟前
木木完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
JamesPei应助科研通管家采纳,获得10
1分钟前
彭于晏应助科研通管家采纳,获得10
1分钟前
如意2023完成签到 ,获得积分10
1分钟前
fomo完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022