小RNA
纤维化
马拉特1
Wnt信号通路
煤气5
生物
长非编码RNA
发病机制
核糖核酸
信号转导
癌症研究
生物信息学
病理
医学
细胞生物学
免疫学
基因
遗传学
作者
Soudeh Ghafouri‐Fard,Atefe Abak,Seyedeh Fahimeh Talebi,Hamed Shoorei,Wojciech Branicki,Mohammad Taheri,Nader Akbari Dilmaghani
标识
DOI:10.1016/j.biopha.2021.112132
摘要
Fibrosis is the endpoint of pathological remodeling. This process contributes to the pathogenesis of several chronic disorders and aging-associated organ damage. Different molecular cascades contribute to this process. TGF-β, WNT, and YAP/TAZ signaling pathways have prominent roles in this process. A number of long non-coding RNAs and microRNAs have been found to regulate organ fibrosis through modulation of the activity of related signaling pathways. miR-144-3p, miR-451, miR-200b, and miR-328 are among microRNAs that participate in the pathology of cardiac fibrosis. Meanwhile, miR-34a, miR-17-5p, miR-122, miR-146a, and miR-350 contribute to liver fibrosis in different situations. PVT1, MALAT1, GAS5, NRON, PFL, MIAT, HULC, ANRIL, and H19 are among long non-coding RNAs that participate in organ fibrosis. We review the impact of long non-coding RNAs and microRNAs in organ fibrosis and aging-related pathologies.
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