塞来昔布
医学
骨关节炎
氨基葡萄糖
不利影响
血沉
内科学
类风湿性关节炎
胃肠病学
麻醉
病理
有机化学
化学
替代医学
作者
Jin Zhang,Ruiyi Ge,Ziquan Yang
出处
期刊:Pakistan Journal of Pharmaceutical Sciences
[Pakistan Journal of Pharmaceutical Sciences]
日期:2021-05-01
卷期号:34: 1277-1282
被引量:5
摘要
To explore the role of celecoxib with glucosamine hydrochloride on functional recovery and reduction of inflammatory factors in patients with knee osteoarthritis. Altogether 128 patients with knee osteoarthritis in the middle and early stage admitted to our hospital from January 2018 to July 2019 were selected and grouped into the control group (CG) (celecoxib tablet therapy) and the combination group (ComG) (celecoxib combined with glucosamine hydrochloride therapy). Blood routine indexes and inflammatory factor levels before and after intervention, Lequesne score, VAS pain and adverse reactions of the two groups of patients before and after intervention were explored. Before intervention, there was no evident difference between the two groups in each index (P>0.05). After intervention, the blood routine index IgM rheumatoid factor, albumin/globulin, erythrocyte sedimentation rate and inflammatory factors TNF-α, IL-6, IL-1β, hs-CRP levels in the ComG were evidently better than those in the CG, while Lequesne score and VAS pain score were lower than those in the CG (P<0.01). The total incidence of adverse reactions in the ComG was evidently lower than that in the CG. Celecoxib combined with glucosamine hydrochloride is effective in the treatment of knee osteoarthritis and has little adverse reactions.
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