子宫内膜异位症
自噬
子宫肌瘤
肌层
促炎细胞因子
子宫内膜
医学
激素
病理生理学
生理学
子宫
生物信息学
内科学
妇科
生物
炎症
遗传学
细胞凋亡
作者
Paola Marcolongo,Emilia Maellaro,Stefano Luisi
出处
期刊:F&S reviews
[Elsevier]
日期:2022-01-01
卷期号:3 (1): 69-75
被引量:3
标识
DOI:10.1016/j.xfnr.2021.11.003
摘要
Endometriosis and uterine fibroids are 2 common gynecological disorders. Their pathophysiology remains unclear, although several different risk factors have been identified, including genetic predisposition, hormones, and proinflammatory cytokines. The present review outlines the experimental evidence showing the role of autophagy in the physiology of the endometrium and myometrium and emerging evidence that autophagy may contribute to the onset of endometriosis and uterine fibroids. The full definition of the role of autophagy is likely to lead to effective new pharmacologic treatments for these disorders. Endometriosis and uterine fibroids are 2 common gynecological disorders. Their pathophysiology remains unclear, although several different risk factors have been identified, including genetic predisposition, hormones, and proinflammatory cytokines. The present review outlines the experimental evidence showing the role of autophagy in the physiology of the endometrium and myometrium and emerging evidence that autophagy may contribute to the onset of endometriosis and uterine fibroids. The full definition of the role of autophagy is likely to lead to effective new pharmacologic treatments for these disorders.
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