Biomechanical Motion‐Activated Endogenous Wound Healing through LBL Self‐Powered Nanocomposite Repairer with pH‐Responsive Anti‐Inflammatory Effect

Abstract Wound care is still worthy of concern, and effective measures such as electrical stimulating therapy (EST) have sparked compellingly for wound repair. Especially, portable and point‐of‐care EST devices get extremely desired but these are often limited by inevitable external power sources, lack of biological functions, and mechanical properties conforming to skin tissue. Herein, a dress‐on‐person self‐powered nanocomposite bioactive repairer of wound is designed. As such, the cooperation of the film prepared by layer‐by‐layer self‐assembling 2‐hydroxypropyltrimethyl ammonium chloride chitosan (HTCC), alginate (ALG), and poly‐dopamine/Fe 3+ nanoparticles (PFNs), with a self‐powered nanogenerator (SN) driven by motion into a nanocomposite repairer (HAP/SN‐NR) is conducted. The HAP/SN‐NR not only guides cell behavior (proliferation and migration rate ≈61.7%, ≈52.3%), but also facilitates neovascularization (enhanced CD31 expression >4‐fold) through its self‐powered EST, and the endogenous wound closure with no inflammatory in rats owing to reactive oxygen species (ROS)‐clearance of HAP/SN‐NR in vitro / vivo through responsively releasing poly‐dopamine nanoparticles at wound pH. Enormous efforts illustrate that the repairer is endowed with high self‐adhesion to tissue, self‐healing, and biodegradation, accelerating wound healing (50% closure ≈5 days). This strategy sheds light on novel multifunctional portable sensor‐type dressings and propels the development of intelligent medical devices.