化学
环异构化
对映选择合成
催化作用
立体化学
组合化学
对映体
有机化学
光学活性
作者
Jingwen Zeng,Wei Fang,Bijin Lin,Gen-Qiang Chen,Xumu Zhang
标识
DOI:10.1021/acs.orglett.1c04171
摘要
The transition-metal-catalyzed asymmetric cycloisomerization of 1,7-enynes is regarded as a formidable challenge due to the poor ability of 1,7-enynes to serve as bidentate ligands to metal. In this Letter, a highly enantioselective rhodium(I)-catalyzed Alder-ene-type cycloisomerization of 1,7-enynes is disclosed, offering an efficient method for the synthesis of a wide range of fused six-membered cyclic compounds. Furthermore, a high turnover frequency experiment and deuterium-labeling experiment were performed to give insight into this transformation.
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