粘附
巨噬细胞极化
材料科学
体外
脚手架
细胞生物学
复合数
内皮干细胞
生物医学工程
巨噬细胞
化学
医学
复合材料
生物
生物化学
作者
Fan Zhang,Hui Tao,Jessica M. Gluck,Lu Wang,Mani A. Daneshmand,Martin W. King
出处
期刊:Soft Matter
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:19 (8): 1624-1641
被引量:2
摘要
At the present time, there is no successful off-the-shelf small-caliber vascular graft (<6 mm) for the repair or bypass of the coronary or carotid arteries. In this study, we engineer a textile-reinforced hydrogel vascular graft. The textile fibers are circularly knitted into a flexible yet robust conduit to serve as the backbone of the composite vascular graft and provide the primary mechanical support. It is embedded in the hydrogel matrix which seals the open structure of the knitted reinforcement and mediates cellular response toward a faster reendothelialization. The mechanical properties of the composite vascular graft, including bursting strength, suture retention strength and radial compliance, significantly surpass the requirement for the vascular graft application and can be adjusted by altering the structure of the textile reinforcement. The addition of hydrogel matrix, on the other hand, improves the survival, adhesion and proliferation of endothelial cells in vitro. The composite vascular graft also enhances macrophage activation and upregulates M1 and M2 related gene expression, which further improves the endothelial cell migration that might favor the reendothelialization of the vascular graft. Taken together, the textile-reinforced hydrogel shows it potential to be a promising scaffold material to fabricate a tissue engineered vascular graft.
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