Biomarkers of hypoxic–ischemic encephalopathy: a systematic review

医学 烯醇化酶 脑病 胶质纤维酸性蛋白 缺氧缺血性脑病 内科学 围产期窒息 小儿外科 生物信息学 病理 窒息 儿科 外科 免疫组织化学 生物
作者
Inês Caramelo,Margarida Coelho,Miguel Rosado,Carla M. P. Cardoso,Alexandra Dinis,Carlos B. Duarte,Mário Grãos,Bruno Manadas
出处
期刊:World Journal of Pediatrics [Springer Nature]
卷期号:19 (6): 505-548 被引量:15
标识
DOI:10.1007/s12519-023-00698-7
摘要

Abstract Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement tools. Therefore, this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice (PROSPERO ID: CRD42021272610). Data sources Searches were performed in PubMed, Web of Science, and Science Direct databases until November 2020. English original papers analyzing samples from newborns > 36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were included. Bias was assessed by the Newcastle–Ottawa Scale. The search and data extraction were verified by two authors separately. Results From 373 papers, 30 met the inclusion criteria. Data from samples collected in the first 72 hours were extracted, and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal asphyxia. In addition, the levels of glial fibrillary acidic protein, ubiquitin carboxyl terminal hydrolase isozyme-L1, glutamic pyruvic transaminase-2, lactate, and glucose were elevated in newborns diagnosed with hypoxic–ischemic encephalopathy. Moreover, pathway analysis revealed insulin-like growth factor signaling and alanine, aspartate and glutamate metabolism to be involved in the early molecular response to insult. Conclusions Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers, since they are correlated with an unfavorable outcome of hypoxic–ischemic encephalopathy newborns. However, more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.
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