中脑
内科学
生物
化学
蓝斑
黑质
多巴胺能
内分泌学
作者
Jason Shumake,Emmeline Edwards,Francisco González-Lima
出处
期刊:Brain Research
[Elsevier]
日期:2003-02-01
卷期号:963 (1-2): 274-281
被引量:204
标识
DOI:10.1016/s0006-8993(02)04048-9
摘要
Congenitally helpless rats have been selectively bred to display an immediate helpless response to stress in order to model hereditary brain differences that contribute to depression vulnerability. Differences in regional brain metabolism between congenitally helpless and non-helpless rats were investigated using quantitative cytochrome oxidase histochemistry. The results indicated that congenitally helpless rats had 64-71% elevated metabolism in the habenula and a 25% elevation in the related interpeduncular nucleus. In contrast, helpless rats had 28% reduced metabolism in the ventral tegmental area (VTA) and 14-16% reductions in the basal ganglia and basolateral and central amygdala. The opposite metabolic changes in the habenula and ventral tegmental area may be especially important for determining the congenitally helpless rat's global pattern of brain activity, which resembles the metabolic activity pattern produced by dopamine antagonism.
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