Zinc-Bound Thiolate−Disulfide Exchange: A Strategy for Inhibiting Metallo-β-lactamases
组合化学
半胱氨酸
金属
活动站点
作者
Heidi Boerzel,Margery Koeckert,Weiming Bu,Bernhard Spingler,Stephen J. Lippard
出处
期刊:Inorganic Chemistry [American Chemical Society] 日期:2003-02-01卷期号:42 (5): 1604-1615被引量:56
标识
DOI:10.1021/ic025624f
摘要
The mononuclear zinc thiolate complexes [(TpPhMe)Zn(S-R)], where TpPhMe is hydrotris((3-methyl-5-phenyl)pyrazolyl)borate and (S-R) is benzyl thiolate, 4-nitrophenylthiolate, 4-trifluoromethylphenyl...