雌激素受体
恶性肿瘤
乳腺癌
孕酮受体
医学
病理
乳房成像
阶段(地层学)
前瞻性队列研究
接收机工作特性
卡帕
表皮生长因子受体
癌症
肿瘤科
内科学
乳腺摄影术
生物
古生物学
语言学
哲学
作者
Zhou Liu,Jie Wen,Meng Wang,Ya Ren,Qian Yang,Long Qian,Honghong Luo,Sha Feng,Cuiju He,Xin Liu,Yin Wu,Dehong Luo
摘要
Amide proton transfer (APT) imaging has been increasingly applied in tumor characterization. However, its value in evaluating breast cancer remains undetermined.To assess the diagnostic performance of APT imaging in breast cancer and its association with prognostic histopathologic characteristics.Prospective.Eighty-four patients with breast lesions.A 3.0 T/single-shot fast spin echo APT imaging.APTw signal in breast lesion was quantified. Lesion malignancy, T stage, grades, Ki-67 index, molecular biomarkers (estrogen receptor [ER] expression, progesterone receptor [PR] expression, human epidermal growth factor receptor [HER-2] expression), molecular subtypes (luminal A, luminal B, triple negative, and HER-2 enriched) were determined.Student t-test, one-way analysis of variance, receiver operating characteristic analysis, and Pearson's correlation with P < 0.05 as statistical significance.APTw signal was significantly higher in malignant lesions (1.55% ± 1.24%) than in benign lesions (0.54% ± 1.13%), and in grade III lesions than in grade II lesions (1.65% ± 0.84% vs. 0.96% ± 0.96%), and in T2- (1.57% ± 0.64%) and T3-stage lesions (1.54% ± 0.63%) than in T1-stage lesions (0.81% ± 0.64%) for invasive breast carcinoma of no special type. APTw signal significantly correlated with Ki-67 index (r = 0.364) but showed no significant difference in groups of ER (P = 0.069), PR (P = 0.069), HER-2 (P = 0.961), and among molecular subtypes (P = 0.073).APT imaging shows potential in differentiating breast lesion malignancy and associates with prognosis-related tumor grade, T stage, and proliferative activity.2 TECHNICAL EFFICACY: Stage 2.
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