电生理学
脑-机接口
计算机科学
多电极阵列
信号(编程语言)
工件(错误)
光电效应
神经科学
微电极
材料科学
人工智能
脑电图
电极
化学
光电子学
生物
物理化学
程序设计语言
作者
Qingda Xu,Ye Xi,Longchun Wang,Zhiyuan Du,Mengfei Xu,Tao Ruan,Jiawei Cao,Kunyu Zheng,Xiaolin Wang,Bin Yang,Jingquan Liu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-08-28
标识
DOI:10.1021/acsnano.4c07379
摘要
Opto-electrophysiology neural probes targeting single-cell levels offer an important avenue for elucidating the intrinsic mechanisms of the nervous system using different physical quantities, representing a significant future direction for brain–computer interface (BCI) devices. However, the highly integrated structure poses significant challenges to fabrication processes and the presence of photoelectric artifacts complicates the extraction and analysis of target signals. Here, we propose a highly miniaturized and integrated opto-electrophysiology neural probe for electrical recording and optical stimulation at the single-cell/subcellular level. The design of a total internal reflection layer addresses the photoelectric artifacts that are more pronounced in single-cell devices compared to conventional implantable BCI devices. Finite element simulations and electrical signal tests demonstrate that the opto-electrophysiology neural probe eliminates the photoelectric artifacts in the time domain, which represents a significant breakthrough for optoelectrical integrated BCI devices. Our proposed opto-electrophysiology neural probe holds substantial potential for promoting the development of in vivo BCI devices and developing advanced therapeutic strategies for neurological disorders.
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