Gallic acid functionalized silk fibroin/gelatin composite wound dressing for enhanced wound healing

丝素 伤口愈合 明胶 生物相容性 静电纺丝 材料科学 纳米纤维 生物医学工程 医学 丝绸 外科 化学 复合材料 生物化学 冶金 聚合物
作者
Ping Li,Ding Zhong Tan,A. C. Su,Xingliang Xiong,Shasha Gao,Haiyang Zhang,Jiaqi Yang,Jie Jian,Jun Zheng,Qifeng Jiang
出处
期刊:Biomedical Materials [IOP Publishing]
标识
DOI:10.1088/1748-605x/ad8c09
摘要

Abstract ABSTRACT
As the incidence of chronic wounds increases, the requirements for wound dressings are rising. The specific aim of this study is to propose a novel gallic acid (GA) functionalized silk fibroin (SF) and gelatin (Gel) composite wound dressing in which GA is used as an antibacterial and wound healing substance. Via electrospinning, SF, Gel, and GA mixed solutions could be conveniently fabricated into a composite nanofiber mat (SF-Gel-GA), consisting of uniform fibers with an average diameter around 134.57 ± 84 nm. The internal mesh structure of SF-Gel-GA provides sufficient drug loading capacity, proper moisture permeability, and proper degradation rate. SF-Gel-GA presents excellent biocompatibility. NIH-3T3 fibroblast cells could adhere and spread stably on the SF-Gel-GA surface with slightly promoted proliferation. In the presence of SF-Gel-GA, the growth of both Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, is significantly inhibited in both plate and suspension cultures. A cutaneous excisional mouse wound model proves the efficient ability of SF-Gel-GA to promote wound healing. Compared with pure SF dressing and commercial Tegaderm Hydrocolloid3M dressing, the wound closure rate with SF-Gel-GA treatment is significantly improved. The histological assessments further demonstrate SF-Gel-GA could facilitate collagen deposition, neovascularization, and epithelialization at wound sites to promote wound healing. In conclusion, a novel SF-Gel-GA composite wound dressing with efficient wound healing activities have been developed for chronic wound treatment with broad healing potential.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
寻道图强应助朱制氢采纳,获得50
刚刚
李总要发财小苏发文章完成签到,获得积分10
1秒前
2011509382发布了新的文献求助10
2秒前
盒子应助kHz采纳,获得10
4秒前
虚幻靖易应助mtfx采纳,获得10
4秒前
kerr完成签到 ,获得积分10
5秒前
阿里发布了新的文献求助10
5秒前
Gauss应助清脆代桃采纳,获得30
6秒前
XX应助科研通管家采纳,获得10
6秒前
小蘑菇应助科研通管家采纳,获得10
7秒前
迷路的台灯完成签到 ,获得积分10
7秒前
周一完成签到,获得积分10
7秒前
老阎应助科研通管家采纳,获得30
7秒前
酷波er应助科研通管家采纳,获得10
7秒前
SciGPT应助科研通管家采纳,获得10
7秒前
穆紫应助科研通管家采纳,获得10
7秒前
orixero应助科研通管家采纳,获得10
7秒前
研友_VZG7GZ应助虚心的访烟采纳,获得10
8秒前
深情安青应助科研通管家采纳,获得10
8秒前
大个应助科研通管家采纳,获得10
8秒前
彭于晏应助科研通管家采纳,获得10
8秒前
慕青应助科研通管家采纳,获得10
8秒前
8秒前
上官若男应助科研通管家采纳,获得10
9秒前
9秒前
9秒前
10秒前
10秒前
赘婿应助robi采纳,获得10
12秒前
ZJHYNL应助xiao123789采纳,获得10
13秒前
2011509382完成签到,获得积分10
14秒前
不安雅琴发布了新的文献求助10
15秒前
Siri完成签到,获得积分10
15秒前
情怀应助冷漠的冰激凌采纳,获得10
15秒前
MR_Z完成签到,获得积分10
17秒前
嗯哼发布了新的文献求助10
18秒前
19秒前
mengjiali完成签到,获得积分10
19秒前
21秒前
kHz完成签到,获得积分10
25秒前
高分求助中
中国国际图书贸易总公司40周年纪念文集 大事记1949-1987 2000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Basic Modern Theory of Linear Complex Analytic 𝑞-Difference Equations 510
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3058597
求助须知:如何正确求助?哪些是违规求助? 2714676
关于积分的说明 7441656
捐赠科研通 2360028
什么是DOI,文献DOI怎么找? 1250485
科研通“疑难数据库(出版商)”最低求助积分说明 607447
版权声明 596421