The functioning of organic compounds, especially aromatic heterocyclic compounds, is the most effective and economical method of corrosion inhibition of metallic materials such as iron, aluminum, copper and their alloys. The present review article first describes recent developments in isatin and its derivatives as a new, efficient and green N-heterocyclic class of organic corrosion inhibitors. The molecular structure of isatin and its derivatives are more comfortable for developing the next generation of corrosion inhibitors having the following characteristics: chemically stable, high thermal activity, excellent antibacterial agents, low toxicity, biocompatibility, good water solubility and non-flammable. The anodic and cathodic acts on the metal surface are blocked maximally by the amino functional group of isatin rings. These inhibitors are mixed-type inhibitors as they retard both anodic and cathodic Tafel reactions. In future research, the isatin rings would be modified with the carbo dots, polymers, nanocarriers, ionic liquids, and surfactants, which would be dominant in corrosion inhibition analysis.