Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation
医学
体外膜肺氧合
充氧
心脏病学
内科学
作者
Mousa Kharnaf,Farhan Zafar,Spencer Hogue,Leah Rosenfeldt,Rachel Cantrell,Bal Krishan Sharma,Amelia Pearson,Cassandra Sprague,Daniel Leino,William Abplanalp,Wioleta M. Zelek,Keith R. McCrae,Youngseon Shim,David L.S. Morales,James S. Tweddell,Joseph E. Qualls,Joseph S. Palumbo
Factor XII (FXII) is a multifunctional protease capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in extracorporeal membrane oxygenation (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not been studied. We used novel gene-targeted FXII- deficient rats to evaluate the role of FXII in ECMO-induced thromboinflammation.