彭布罗利珠单抗
吉西他滨
医学
肿瘤科
胰腺癌
腺鳞癌
微卫星不稳定性
内科学
种系突变
体细胞
癌症研究
化疗
腺癌
癌症
突变
免疫疗法
生物
生物化学
等位基因
微卫星
基因
作者
Rodrigo Paredes,James Doolin,Mary Linton B. Peters
出处
期刊:Case Reports
[BMJ]
日期:2023-02-01
卷期号:16 (2): e251936-e251936
被引量:2
标识
DOI:10.1136/bcr-2022-251936
摘要
A previously healthy man in his 60s was diagnosed with a rare histological subtype of pancreatic cancer, adenosquamous carcinoma. After somatic mutation profiling, it was found that the tumour had microsatellite instability status high and a high tumour mutational burden. The patient was started on combination therapy with gemcitabine, nab-paclitaxel and pembrolizumab. Tumour size and biomarkers showed a dramatic response eventually leading to the patient being transitioned to maintenance therapy with pembrolizumab. The patient has demonstrated continued response since the start of the treatment. This is the first report in the literature showing a sustained response in this type of neoplasm that was treated with a checkpoint inhibitor, and thus adds to the evidence supporting universal somatic testing in all pancreatic cancers for a tailored approach to therapy.
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