Applications of metal organic frameworks in point of care testing

Diagnostic devices used in the point-of-care (POC) today play a critical role as tools to provide essential medical surveillance data and to ensure that patients receive appropriate and timely care. These devices also allow self-analysis by the patient, increasing therapeutic adherence as well as reducing pressure on clinical structures. The development of new diagnostic tools, therefore, represents a significant challenge from a technological point of view, both in terms of overcoming current weaknesses in costs, accuracy, and performance, and from an analytical point of view in order to develop tools that are as operator-independent as possible. Recent breakthroughs in new technologies (such as cell phone-dependent technologies, paper-based procedures, and lab-on-a-chip devices) are paving the way for the next generation of point-of-care testing (POCT). Innovative assay devices, as well as efficient reagent storage techniques, are required for new POCT technologies. Nanomaterials of different forms, sizes, and compositions, such as carbon nanomaterials, quantum dots, gold and silver nanoparticles, mesoporous silica nanoparticles, and metal-organic frameworks (MOFs), have been created and characterized in recent years. Due to their specific physicochemical properties, MOF nanoparticles are increasingly being used in POCT to improve analytical performance and simplify testing techniques. MOFs have been used for colorimetric or electrochemical POCT and are used as carriers for plasmonic biosensors to be resistant to environmental conditions. This review will discuss the detailed role of MOF in POCT from 2016 to 2023, in addition to the chemical synthesis and characterization methods related to the uses and applications of MOF.