表征(材料科学)
荧光
化学
荧光寿命成像显微镜
组合化学
纳米技术
材料科学
物理
光学
作者
Seenivasagaperumal Sriram Babu,Natarajan Savitha Devi,Reena Devi,Narayanan Kannan,Sivakumar Shanmugam
标识
DOI:10.1002/slct.202303884
摘要
Abstract Biologically‐active near‐ultraviolet emitting spirooxindole‐pyrrolidine/pyrrolothiazole‐β‐ketothiolester have been synthesised via Chemo‐/regio‐/stereoselective manner. Excited‐state intramolecular proton transfer (ESIPT) of β‐ketothiolester exhibits excitation‐dependent emission with intermolecular hydrogen bonding ability with solvents. The emission could be tunable between 330 nm to 460 nm. Selected fluorescent compounds 4{4,2,1}, 4{12,2,2}, 5{4,2,1} and 5{12,2,2} shows cytotoxicity effect on PC3 cells, where the highest IC 50 value (6 μM) was found for the probe 5{12,2,2}. The fluorescent behavior of 5{4,2,1} and 5{12,2,2} acted as an imaging molecule against cancer cells.
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