The histopathology of very early onset-IBD

Dear editor, Understanding endoscopic and clinicopathological features of patients with very early onset inflammatory bowel disease: Results from a decade of studyDigestive and Liver DiseaseVol. 56Issue 1PreviewVery early onset inflammatory bowel disease (VEOIBD) is associated with a unique disease course and distinct endoscopic features. Full-Text PDF Very early onset inflammatory bowel diseases: Is it the time to share and define a histopathological reporting scheme?Digestive and Liver DiseaseVol. 56Issue 4PreviewWe read with interest the paper from Ye et al. [1] concerning endoscopic and clinicopathologic features of children with a clinical diagnosis of Very Early Onset Inflammatory Bowel Diseases (VEO-IBD). This study is one of the largest on the topic, with 225 patients included, 198 of whom with intestinal biopsies [1]. Interestingly, a comparison of morphological features retrospectively acquired from histological reports (chronic architectural damage, apoptoses, eosinophilic infiltration, small bowel villous blunting, active inflammation, intraepithelial lymphocytosis, and granulomas) showed intraepithelial lymphocytosis, apoptosis and eosinophils infiltration were significantly more common among non-monogenic IBD patients. Full-Text PDF