生物生产
代谢工程
商品化学品
2,3-丁二醇
生化工程
发酵
合成生物学
可持续生产
化学
生产(经济)
生物催化
纳米技术
生物技术
生物
计算生物学
酶
工程类
材料科学
生物化学
经济
催化作用
离子液体
宏观经济学
作者
Jie Cheng,Juan Li,Linggang Zheng
标识
DOI:10.1021/acs.jafc.1c03769
摘要
1,4-Butanediol (1,4-BDO), a significant commodity chemical, is currently manufactured exclusively from a host of energy-intensive processes, accompanied by severe environmental issues, such as the greenhouse effect and air pollution. As a result of the ever-increasing global market demands and increasing applications of 1,4-BDO, attention has turned to the sustainable bioproduction of 1,4-BDO, and several bio-based approaches for 1,4-BDO production have been successfully established in engineered Escherichia coli, including de novo biosynthesis and biocatalysis. Recent achievements in enhancing the accumulation of 1,4-BDO have been achieved by metabolic engineering strategies, such as improving precursor supply, enhancing activities of critical enzymes, and fewer byproduct synthesis. Here, we summarize the primary advances of the biological pathway for 1,4-BDO synthesis and put forward the future development prospect of bio-based 1,4-BDO production.
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