遗传密码
氨基酸
蛋白质二级结构
蛋白质进化
蛋白质结构
生物
遗传学
突变
测试表
冗余(工程)
氨基酸取代
计算生物学
生物化学
基因
计算机科学
操作系统
标识
DOI:10.1016/s0022-5193(85)80272-1
摘要
The genetic code has an inherent bias towards some amino acids because of the variable number of synonymous codons per amino acid. The extent to which these biases are expressed in protein secondary structure is described through the analysis of the overall amino acid compositions of the alpha-helix, beta-sheet, beta-turn and random coil segments elucidated by X-ray crystallography. Given the concept of neutral mutation in proteins, the allocation of synonyms in the genetic code appears to protect secondary structures from amino acid changes and discourages the appearance of chemically complex residues. The level of protection is similar for each structural form, despite their clear preferences for certain amino acids. The organization of the code is therefore relevant to the preservation of conformation seen in the evolution of many protein families.
科研通智能强力驱动
Strongly Powered by AbleSci AI