淋巴瘤
癌症研究
皮肤T细胞淋巴瘤
肿瘤微环境
T细胞
骨髓
单克隆抗体
免疫学
医学
炎症
抗体
生物
蕈样真菌病
肿瘤细胞
免疫系统
作者
Xuesong Wu,Daniel K. Hsu,Kang-Hsin Wang,Yuanshen Huang,Lindsay Mendoza,Youwen Zhou,Sam T. Hwang
标识
DOI:10.1080/10428194.2018.1516037
摘要
A crucial question pertains to a role of IL-10 as a tumorigenic factor, or just a marker of advanced disease in cutaneous T-cell lymphoma (CTCL). Herein, we measured significantly elevated IL-10 mRNA in a cohort of skin samples of patients with CTCL. Increased IL-10 was also detected in the tumor microenvironment of an established inflammation-dependent murine model of using MBL2 T lymphoma cells. Conditioned media from MBL2 cells was able to stimulate IL-10 production in bone marrow-derived macrophages in an IL-4-dependent manner. Implanted MBL2 T-cell lymphomas in IL-10KO mice were 50% smaller, accompanied by decreased numbers of infiltrating macrophages and reduced efficiency of M2-polarization compared with wild-type mice. With anti-IL-10R mAb treatment, both wild-type tumor-bearing mice and IL-10KO mice exhibited a further growth inhibition. Our data indicate that targeting IL-10 signaling with neutralizing antibodies to IL-10 or its receptor may have a great potential for advanced CTCL therapy.
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