甘油磷酯
细菌外膜
心磷脂
脂多糖
革兰氏阴性菌
心磷脂
生物
甘油磷脂
细胞生物学
膜
细菌
化学
微生物学
生物化学
大肠杆菌
磷脂
免疫学
遗传学
基因
作者
Martin V. Douglass,François Cléon,M. Stephen Trent
标识
DOI:10.1073/pnas.2018329118
摘要
Significance The outer membrane of gram-negative bacteria is a major deterrent for antibiotic entry, making it difficult to treat these infections. It is composed of both LPS and glycerophospholipids, where the synchronized synthesis between these two components is essential for the outer membrane’s unique permeability barrier. In this report, we identify a previously unidentified association between LPS and glycerophospholipids, where the presence of the complete repertoire of glycerophospholipids is required for efficient transport of LPS. Our results provide insight into how E. coli modifies its lipid composition to maintain the outer membrane’s formidable barrier function.
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