磷酰胺
化学
前药
部分
核苷
立体化学
膦酸盐
组合化学
选择性
替诺福韦-阿拉芬酰胺
衍生工具(金融)
生物化学
病毒学
病毒
抗逆转录病毒疗法
经济
催化作用
病毒载量
金融经济学
生物
标识
DOI:10.1021/acs.jmedchem.1c01908
摘要
In this issue of the Journal of Medicinal Chemistry, Janeba et al. found that the in vitro antiviral activity and selectivity index of the aryloxy phosphoramidate (ProTide) prodrug of the acyclic nucleoside phosphonate tenofovir (tenofovir alafenamide) can be dramatically improved by replacing the aryloxy pro-moiety with an appropriate tyrosine derivative. This Viewpoint highlights the possible impact and ramifications that these findings may have in the development of new ProTides.
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