Numerical modelling of osteocyte growth on different bone tissue scaffolds

骨细胞 脚手架 生物医学工程 材料科学 剪应力 生物反应器 骨整合 再生(生物学) 组织工程 骨生长 细胞生长 化学 成骨细胞 复合材料 细胞生物学 植入 医学 生物 外科 内科学 有机化学 体外 生物化学
作者
Concepción Paz,Eduardo Suárez,C. Gil,Oscar Parga
出处
期刊:Computer Methods in Biomechanics and Biomedical Engineering [Informa]
卷期号:25 (6): 641-655 被引量:5
标识
DOI:10.1080/10255842.2021.1972290
摘要

The most common solution for the regeneration or replacement of damaged bones is the implantation of prostheses comprising ceramic or metallic materials. However, these implants are known to cause problems such as post-operative infections, collapse of the prosthesis, and lack of osseointegration. Consequently, bone tissue engineering was established because of the limitations of such implants. Osteogenic implants offer promising solutions for bone regeneration; however, three-dimensional scaffolds should be used as supportive structures. It is challenging to correctly design these structures and their compositions or properties to provide a microenvironment that promotes tissue regeneration and expedites bone formation. Computational fluid dynamics can be used to model the main phenomena that occur in bioreactors, such as cell metabolism, nutrient transport, and cell culture growth, or to model the influence of several key mechanisms related to the fluid medium, in particular, the wall shear stress. In this work, a new numerical bone cell growth model was developed, which considered the oxygen and nutrient consumption as well as the wall shear stress effect on cell proliferation. The model was implemented using 35 three-dimensional scaffolds of different porosities, and the effect of the main geometrical parameters involved in each scaffold type was analysed. The porosity plays an important role, however, a similar porosity did not guarantee similar shear stress or cell growth among the scaffolds. Randomised trabecular scaffolds, that more closely resembled trabecular bone, showed the highest cell growth values, so these are the best candidates for cell growth in a bioreactor.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
Zz完成签到 ,获得积分10
1秒前
橡皮泥发布了新的文献求助30
2秒前
guoguo82完成签到,获得积分10
2秒前
ymX发布了新的文献求助50
2秒前
Neko完成签到,获得积分10
3秒前
liu完成签到,获得积分10
3秒前
拼搏小丸子完成签到 ,获得积分10
4秒前
4秒前
orixero应助谦让的指甲油采纳,获得10
5秒前
Arvilzzz完成签到,获得积分10
7秒前
害羞的裘完成签到 ,获得积分10
7秒前
冷酷的小懒猪完成签到 ,获得积分10
8秒前
9秒前
Hello应助青青草原图图采纳,获得10
9秒前
漂亮的飞莲完成签到,获得积分10
10秒前
科研通AI5应助邱邱采纳,获得30
10秒前
宋枝野完成签到 ,获得积分10
10秒前
11秒前
12秒前
dyc238100完成签到,获得积分10
12秒前
hipig发布了新的文献求助10
14秒前
14秒前
14秒前
风趣的烤鸡完成签到,获得积分20
15秒前
赘婿应助耍酷的白桃采纳,获得10
15秒前
仲夏夜之梦完成签到,获得积分10
16秒前
共享精神应助然大宝采纳,获得10
16秒前
16秒前
xx完成签到 ,获得积分10
16秒前
Arvilzzz发布了新的文献求助10
17秒前
17秒前
达芙发布了新的文献求助10
17秒前
998877剑指完成签到,获得积分10
18秒前
zq1992nl完成签到,获得积分10
21秒前
搜集达人应助大白杨采纳,获得10
21秒前
酷波er应助体贴精灵采纳,获得10
21秒前
华仔应助石思炜采纳,获得10
21秒前
CC发布了新的文献求助30
22秒前
任世界灯火阑珊完成签到,获得积分10
23秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572102
求助须知:如何正确求助?哪些是违规求助? 3142380
关于积分的说明 9447398
捐赠科研通 2843806
什么是DOI,文献DOI怎么找? 1563098
邀请新用户注册赠送积分活动 731575
科研通“疑难数据库(出版商)”最低求助积分说明 718603