Numerical modelling of osteocyte growth on different bone tissue scaffolds

骨细胞 脚手架 生物医学工程 材料科学 剪应力 生物反应器 骨整合 再生(生物学) 组织工程 骨生长 细胞生长 化学 成骨细胞 复合材料 细胞生物学 植入 医学 生物 外科 内科学 有机化学 体外 生物化学
作者
Concepción Paz,Eduardo Suárez,C. Gil,Oscar Parga
出处
期刊:Computer Methods in Biomechanics and Biomedical Engineering [Informa]
卷期号:25 (6): 641-655 被引量:5
标识
DOI:10.1080/10255842.2021.1972290
摘要

The most common solution for the regeneration or replacement of damaged bones is the implantation of prostheses comprising ceramic or metallic materials. However, these implants are known to cause problems such as post-operative infections, collapse of the prosthesis, and lack of osseointegration. Consequently, bone tissue engineering was established because of the limitations of such implants. Osteogenic implants offer promising solutions for bone regeneration; however, three-dimensional scaffolds should be used as supportive structures. It is challenging to correctly design these structures and their compositions or properties to provide a microenvironment that promotes tissue regeneration and expedites bone formation. Computational fluid dynamics can be used to model the main phenomena that occur in bioreactors, such as cell metabolism, nutrient transport, and cell culture growth, or to model the influence of several key mechanisms related to the fluid medium, in particular, the wall shear stress. In this work, a new numerical bone cell growth model was developed, which considered the oxygen and nutrient consumption as well as the wall shear stress effect on cell proliferation. The model was implemented using 35 three-dimensional scaffolds of different porosities, and the effect of the main geometrical parameters involved in each scaffold type was analysed. The porosity plays an important role, however, a similar porosity did not guarantee similar shear stress or cell growth among the scaffolds. Randomised trabecular scaffolds, that more closely resembled trabecular bone, showed the highest cell growth values, so these are the best candidates for cell growth in a bioreactor.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
纸之治治发布了新的文献求助10
1秒前
3秒前
优秀剑愁完成签到 ,获得积分10
3秒前
4秒前
喃喃发布了新的文献求助10
7秒前
8秒前
顾矜应助大气绿蓉采纳,获得10
9秒前
9秒前
12秒前
12秒前
13秒前
77完成签到,获得积分20
15秒前
18秒前
20秒前
笑点低天德完成签到,获得积分10
20秒前
弱水完成签到,获得积分10
22秒前
单薄的金鱼完成签到,获得积分10
22秒前
默默月光完成签到,获得积分10
23秒前
ananan完成签到,获得积分10
23秒前
纸之治治完成签到,获得积分10
24秒前
大模型应助albertxin采纳,获得10
25秒前
26秒前
yuqinghui98发布了新的文献求助10
26秒前
情怀应助什么都不懂采纳,获得10
28秒前
Owen应助Hana采纳,获得10
31秒前
谁谁谁完成签到,获得积分10
33秒前
猪猪hero应助77采纳,获得10
34秒前
36秒前
冷酷的啤酒完成签到,获得积分10
38秒前
克己复礼完成签到,获得积分10
39秒前
40秒前
迪仔发布了新的文献求助10
41秒前
完美世界应助tkdzjr12345采纳,获得10
41秒前
斯文败类应助虚幻的之卉采纳,获得30
42秒前
飞向天空的牛完成签到,获得积分10
43秒前
43秒前
44秒前
lin发布了新的文献求助40
48秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Exploring the effects of an evidenced-based professional development programme on teaching and learning in Chinese kindergartens 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3576634
求助须知:如何正确求助?哪些是违规求助? 3146582
关于积分的说明 9465813
捐赠科研通 2848133
什么是DOI,文献DOI怎么找? 1565465
邀请新用户注册赠送积分活动 733041
科研通“疑难数据库(出版商)”最低求助积分说明 719546