Investigation of In-vitro anti-Inflammatory, anti-platelet and anti-arthritic activities in the leaves of Anisomeles malabarica Linn

Previous phytochemical analysis of methanolic extract of A. malabarica L. has indicated the presence of steroid, flavonoid and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check A. malabarica L for possible antiinflammatory activity by HRBC (Human Red Blood Cell) membrane stabilization method, anti-arthritic activity by the inhibition of protein denaturation method and anti-platelet activity. The methanolic extracts of the plant exhibited notable anti-inflammatory activity and remarkable anti-arthritic, anti-platelet action. The maximum membrane stabilization of A. malabarica L was found to be 98.34% at a dose of 1000mcg/0.5ml and that of protein denaturation was found to be 97.47% at a dose of 250mcg/ml. Hence, the methanolic extracts of A. malabarica L demonstrated the anti- inflammatory, anti-platelet and anti- arthritic activities. Therefore, our studies support the