纳米材料基催化剂
氧化应激
炎症
锌
活性氧
肺炎
细胞因子
材料科学
微生物学
免疫学
医学
生物
生物化学
纳米技术
纳米颗粒
内科学
冶金
作者
Peilei Liu,Penghao Ji,Liping Wang,Haiyan Guo,Minfeng Huo,Jianlin Shi
出处
期刊:Biomaterials
[Elsevier]
日期:2022-10-01
卷期号:289: 121768-121768
被引量:14
标识
DOI:10.1016/j.biomaterials.2022.121768
摘要
The bacterial pneumonia has been demonstrated to cause acute and severe pathological lung injury as well as the uncontrollable oxidative cytokine storms. The effective therapeutics against bacterial pneumonia demands highly efficient pathogen elimination, oxidative stress alleviation and anti-inflammation. Nevertheless, current therapeutics fail to achieve these goals by a single medicine with satisfactory performance. Herein, we report a self-assembled zinc-doped prussian blue-analogue – zinc hexacyanoferrate nanocatalysts (ZnPBA NCs) possessing excellent broad-spectrum anti-bacterial activity and antioxidative catalytic activities against multiple reactive oxygen species (ROS) and the associated cytokine storm as well. By employing various oxidative substances and in vivo murine bacterial pneumoniae models, we verified that the synthetic zinc hexacyanoferrate nanocatalysts could concurrently eliminate the bacterial infection and largely alleviate infection-induced oxidative stress and inflammation, demonstrating the promising clinical application potentials against diverse bacterial infection-related diseases.
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