光热治疗
材料科学
纳米技术
癌细胞
荧光
荧光寿命成像显微镜
生物医学中的光声成像
光热效应
纳米颗粒
癌症影像学
生物物理学
癌症
医学
生物
光学
内科学
物理
作者
Jie Cui,Fei Zhang,Dingyuan Yan,Ting Han,Lei Wang,Dong Wang,Ben Zhong Tang
标识
DOI:10.1002/adma.202302639
摘要
Multimodal phototheranostics on the basis of a single molecule with one-for-all characteristics represents a convenient approach for effective cancer treatment. In this report, a versatile molecule featured by aggregation-induced emission, namely DHTDP, synchronously enabling second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion is developed by elaborate structural modulation. By camouflaging DHTDP nanoparticles with cancer cell membrane, the resultant biomimetic nanoparticles exhibit significantly both facilitated delivery efficiency and homologous targeting capability, and afford precise imaging guidance and maximize therapeutic outcomes in form of NIR-II fluorescence imaging (FLI)-photoacoustic imaging (PAI)-photothermal imaging (PTI) trimodal imaging-guided photothermal therapy (PTT). This study presents the first example of biomimetic multimodal phototheranostics loaded by homogeneity-targeting cell membrane, thus brings a new insight into the exploration of superior phototheranostics for practical cancer theranostics.
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